Novel nanocages for delivery of small interfering RNAs image:Schematic representation of the use of nanocages for siRNA delivery. When binding siRNA (arrow A), the nanocages with a typical diameter of 5-6 nanometre cluster into cage-RNA nanoparticles with a diameter of some 150 nanometres. This is small enough to enter a…..
Good news for quality control of mRNA medications A mRNA molecule (p-RNA) is mixed with a standard (s-RNA) labelled with stable isotopes (SI) before being digested then characterized using a combination of liquid chromatography and mass spectrometry (LC-MS). The output is analyzed using Ariadne software to yield information on the…..
Genomics study identifies unique set of proteins that restores hearing in zebrafish Study shows the role of transcription factors in facilitating cell regeneration. National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration. The study, led by…..
NIH researchers develop gene therapy for rare ciliopathy Researchers from the National Eye Institute (NEI), part of the National Institutes of Health (NIH), have developed a gene therapy that rescues cilia defects in retinal cells affected by a type of Leber congenital amaurosis (LCA), a disease that causes blindness…..
Why low DNA methylation at H3K27me3 sites for gene repression In our cells, genes associated with alternative cell fate have to be silenced. DNA methylation and H3K27me3 on the histone are two of the most prevalent chromatin modifications that control the epigenetic gene silencing. These two modifications are mutually exclusive…..
First blood test to diagnose bipolar disorder A team involving researchers from Alcediag, Montpellier University Hospital, Les Toises Psychiatry Centre in Lausanne and Professor David J. Kupfer from the University of Pittsburgh identified and validated a combination of blood biomarkers specific to bipolar disorder. These results, recently published in Nature,…..
New perspective on RNA function: RNA regulates proteins and thereby can control cell growth Scientists are increasingly learning of new reasons to appreciate RNA, and the glycolytic enzyme ENO1 seems to have provided yet another in new research from European Molecular Biology Laboratory (EMBL) this week, as published in Molecular…..
New data-driven approach to help reduce drug costs and treat diseases A new data-driven mechanistic approach that predicts cell types within tissue will help to reduce drug costs and treat diseases that were difficult to develop drugs for, according to a West Virginia University scientist. [caption id="attachment_10508" align="aligncenter" width="700"] WVU…..
Experimental siRNA therapy SLN360 shows promise for previously untreatable heart disease risk factor
Experimental siRNA therapy SLN360 shows promise for previously untreatable heart disease risk factor While there are effective therapies to reduce the risk of heart disease by lowering low-density lipoprotein (LDL), or “bad” cholesterol, and other lipids, to date there are no approved treatments to lower lipoprotein(a), a lesser-known driver of…..
Microbiota medicine: towards clinical revolution 21 high-level authors and members of the International Society of Microbiota, coming from 8 countries and more than 10 reputable institutions published a new strategic report titled “Microbiota medicine: towards clinical revolution”. Published in the Journal of Translational Medicine, this stunning review confirms that microbiota…..
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