New perspective on RNA function: RNA regulates proteins and thereby can control cell growth Scientists are increasingly learning of new reasons to appreciate RNA, and the glycolytic enzyme ENO1 seems to have provided yet another in new research from European Molecular Biology Laboratory (EMBL) this week, as published in Molecular…..
New data-driven approach to help reduce drug costs and treat diseases A new data-driven mechanistic approach that predicts cell types within tissue will help to reduce drug costs and treat diseases that were difficult to develop drugs for, according to a West Virginia University scientist. [caption id="attachment_10508" align="aligncenter" width="700"] WVU…..
Experimental siRNA therapy SLN360 shows promise for previously untreatable heart disease risk factor
Experimental siRNA therapy SLN360 shows promise for previously untreatable heart disease risk factor While there are effective therapies to reduce the risk of heart disease by lowering low-density lipoprotein (LDL), or “bad” cholesterol, and other lipids, to date there are no approved treatments to lower lipoprotein(a), a lesser-known driver of…..
Microbiota medicine: towards clinical revolution 21 high-level authors and members of the International Society of Microbiota, coming from 8 countries and more than 10 reputable institutions published a new strategic report titled “Microbiota medicine: towards clinical revolution”. Published in the Journal of Translational Medicine, this stunning review confirms that microbiota…..
New therapy breakthrough could change the shape of treatment for undruggable diseases For some time, scientists have been working on the major challenge of developing new therapies against many human diseases. Many of these diseases are caused by the abberant action of certain proteins in our cells that are…..
New technology allows molecules to enter cells safely Professor Braeckmans from Ghent University focused the last ten years on a method for safe engineering of therapeutic cells with photothermal nanofibers. Now, Nature Nanotechnology gives insight in how these biocompatible photothermal nanofibers were developed, and how, upon laser irradiation, cells…..
A Z-RNA nanoswitch encoded by "junk DNA" turns-off immune responses against self In a paper published in the May 13th, 2021 issue of PLOS Genetics, Dr. Alan Herbert of InsideOutBio, describes how nature uses a nano-scale Z-RNA switch to turn-off immune responses against self. This Z-RNA nanoswitch sequence, less than…..
Novel nanotech improves cystic fibrosis antibiotic by 100,000-fold Cystic fibrosis is causing severe impairments to a person's lungs, airways and digestive system, trapping bacteria and leading to recurrent infections. Lung failure is the major cause of death for people with this disease. World-first nanotechnology developed by the University of South…..
New research on why mutations in a gene leads to mitochondrial disease Image of mitochondria (yellow-green) around the cell nucleus (blue). ©Dr Matthew Eramo Mitochondrial diseases are inherited, chronic illnesses that can present at birth or develop later in life and occurs when mitochondria fail to produce enough energy for…..
Bypassing broken genes Researchers at Penn State have developed a new approach to gene editing using the CRISPR/Cas9 system bypasses disease-causing mutations in a gene, enabling treatment of genetic diseases linked to a single gene, such as cystic fibrosis, certain types of sickle cell anemia, and other rare diseases. The…..
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