NIH researchers develop gene therapy for rare ciliopathy Researchers from the National Eye Institute (NEI), part of the National Institutes of Health (NIH), have developed a gene therapy that rescues cilia defects in retinal cells affected by a type of Leber congenital amaurosis (LCA), a disease that causes blindness…..
Why low DNA methylation at H3K27me3 sites for gene repression In our cells, genes associated with alternative cell fate have to be silenced. DNA methylation and H3K27me3 on the histone are two of the most prevalent chromatin modifications that control the epigenetic gene silencing. These two modifications are mutually exclusive…..
First blood test to diagnose bipolar disorder A team involving researchers from Alcediag, Montpellier University Hospital, Les Toises Psychiatry Centre in Lausanne and Professor David J. Kupfer from the University of Pittsburgh identified and validated a combination of blood biomarkers specific to bipolar disorder. These results, recently published in Nature,…..
New perspective on RNA function: RNA regulates proteins and thereby can control cell growth Scientists are increasingly learning of new reasons to appreciate RNA, and the glycolytic enzyme ENO1 seems to have provided yet another in new research from European Molecular Biology Laboratory (EMBL) this week, as published in Molecular…..
New data-driven approach to help reduce drug costs and treat diseases A new data-driven mechanistic approach that predicts cell types within tissue will help to reduce drug costs and treat diseases that were difficult to develop drugs for, according to a West Virginia University scientist. [caption id="attachment_10508" align="aligncenter" width="700"] WVU…..
Experimental siRNA therapy SLN360 shows promise for previously untreatable heart disease risk factor
Experimental siRNA therapy SLN360 shows promise for previously untreatable heart disease risk factor While there are effective therapies to reduce the risk of heart disease by lowering low-density lipoprotein (LDL), or “bad” cholesterol, and other lipids, to date there are no approved treatments to lower lipoprotein(a), a lesser-known driver of…..
Microbiota medicine: towards clinical revolution 21 high-level authors and members of the International Society of Microbiota, coming from 8 countries and more than 10 reputable institutions published a new strategic report titled “Microbiota medicine: towards clinical revolution”. Published in the Journal of Translational Medicine, this stunning review confirms that microbiota…..
New therapy breakthrough could change the shape of treatment for undruggable diseases For some time, scientists have been working on the major challenge of developing new therapies against many human diseases. Many of these diseases are caused by the abberant action of certain proteins in our cells that are…..
New technology allows molecules to enter cells safely Professor Braeckmans from Ghent University focused the last ten years on a method for safe engineering of therapeutic cells with photothermal nanofibers. Now, Nature Nanotechnology gives insight in how these biocompatible photothermal nanofibers were developed, and how, upon laser irradiation, cells…..
A Z-RNA nanoswitch encoded by "junk DNA" turns-off immune responses against self In a paper published in the May 13th, 2021 issue of PLOS Genetics, Dr. Alan Herbert of InsideOutBio, describes how nature uses a nano-scale Z-RNA switch to turn-off immune responses against self. This Z-RNA nanoswitch sequence, less than…..
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