Date: 2011-11-07
Type of information:
phase: 1-2a
Announcement: results
Company: CureVac (Germany)
Product: CV9201
Action
mechanism: mRNA Based Cancer Vaccine. CureVac´s RNActive® tumor immunotherapy approach is independent of the HLA subtype. CV9201 is one candidate in CureVac’s pipeline of RNActive®-derived molecules for the active immunotherapy of cancer. The vaccine comprises mRNA molecules encoding five different antigens of which three are cancer testis antigens.
Disease: non small cell lung cancer (NSLC)
Therapeutic area: Cancer - Oncology
Country: Germany, Switzerland
Trial details:
Latest
news: CureVac has presented the results of a Phase I/IIa trial in non-small cell lung cancer (NSCLC) with CV9201, an mRNA-based cancer vaccine, in patients with NSCLC stage IIIB/IV after first-line chemo-radiotherapy or chemotherapy, respectively. The trial strived to assess safety and toxicity of CV9201 as well as its ability to induce antigen-specific humoral and cellular immune responses in cancer patients.
The results suggest that CV9201 is safe, well tolerated and biologically active. The trial evaluated a five dose regime of CV9201 delivered via intradermal injection in 46 patients.
The trial with CV9201, conducted in Germany and Switzerland , was the first to test an immunotherapy based on CureVac´s RNActive® vaccination technology in patients after heavy pre-treatment with chemotherapy. 65% of the phase IIa study patients responded to at least one antigen out of the five antigens in CV9201. The therapeutic mRNA vaccine induces responses against multiple antigens in two thirds of immunologically responding patients. A profound B-cell activation could be seen in 61% of the patients.
The results of the NSCLC trial underpin the broad applicability of CureVac’s proprietary RNActive® vaccination technology to generate novel cancer vaccines against tumor-associated antigens. The results are seen as another important validation step of CureVac’s innovative proprietary RNActive® vaccination technology.
