Date: 2012-05-30
Type of information: Licensing agreement
Compound: HuMax-IL8
Company: Genmab (Denmark) Cormorant Pharmaceuticals (Sweden)
Therapeutic area: Cancer - Oncology
Type agreement: licensing
Action mechanism: HuMax-IL8 is a high affinity fully human IgG1,? antibody directed towards IL-8. IL-8 is a major mediator of inflammation, a potent chemoattractant for white blood cells called neutrophils, as well as an important factor in angiogenesis. HuMax-IL8 effectively blocks binding of IL-8 to neutrophils and inhibits neutrophils from migrating towards sites of inflammation via a process known as chemotaxis. HuMax-IL8 also potently inhibits IL-8 induced neutrophil activation. In pre-clinical studies, HuMax-IL8 has been shown to inhibit tumor growth in tumor models using primary human tumors in immunodeficient mice.
Disease: cancer
Details: Genmab has granted an exclusive, worldwide license to its HuMax®-IL8 antibody to Cormorant Pharmaceuticals. Under the terms of the agreement, Genmab will receive an upfront payment and will be entitled to milestone payments and royalties on net sales. Cormorant intends to evaluate HuMax-IL8 for treatment of select cancers and will be responsible for all future costs of developing, manufacturing and commercializing HuMax-IL8.
Financial terms:
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