Date: 2018-01-30

Type of information: Licensing agreement

Compound: pan receptor interacting molecule (PRIM) program

Company: AB Biosciences (USA - MA) Shire (UK - USA)

Therapeutic area: Autoimmune diseases

Type agreement: licensing - development - commercialisation

Action mechanism:

  • immunoglobulin. PRIM (pan receptor interacting molecule) is a novel protein therapeutic for the treatment of autoimmune disorders. Preparation of human IVIg contains immune complexes which in turn contain multiple antibody and antigen molecules that are known to modulate immune responses through their interactions with Fc receptors. PRIM protein contains three immunoglobulin constant regions and can effectively bind to Fc receptors similar to that of immune complexes. In contrast to human IVIg, production of PRIM protein does not require the traditional plasma collection of thousands of individuals and safety tests for infectious agents. Furthermore, without the bulk of monomeric immunoglobulin, PRIM has the potential to be biologically active at lower doses. As such, alternative, non-intravenous routes of administration may be feasible.



  • • On January 30, 2018, AB Biosciences and Shire announced that they have entered into an agreement granting Shire an exclusive worldwide license to develop and commercialize AB Biosciences’ pan receptor interacting molecule (PRIM) program, which uses AB Biosciences’ proprietary oligomeric Fc technology platform. PRIM, a recombinant immunoglobulin product candidate, has shown encouraging preclinical data, including enhanced biological activity relative to currently approved intravenous immunoglobulin (IVIg) therapies, in preclinical models of autoimmune and inflammatory diseases.
  • Under the terms of the agreement, AB Biosciences will grant Shire an exclusive, worldwide license to its intellectual property relating to its PRIM program. AB Biosciences will receive an upfront license fee payment from Shire and is eligible to receive contingent research, development, and commercialization milestone payments as well as royalty payments. No further terms of the agreement were disclosed.

Financial terms:

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