Date: 2016-09-12
Type of information: Licensing agreement
Compound: Anc80 and other Anc-AAVs gene therapy products
Company: Lonza (Switzerland) Massachusetts Eye and Ear® (USA - MA)
Therapeutic area: Technology - Services
Type agreement: licensing
Action mechanism: gene therapy. Anc-AAVs are in silico designed synthetic adeno-associated viral vectors (AAVs), developed first in the laboratory of Dr. Luk H. Vandenberghe, Assistant Professor at Harvard Medical School, and Director of the Grousbeck Gene Therapy Center at Massachusetts Eye and Ear®.
Disease:
Details: * On September 12, 2016, Lonza Houston and Massachusetts Eye and Ear®, the world’s largest vision and hearing research center, have entered into a strategic agreement that provides customers the ability to in-license Anc80 and other Anc-AAVs for the clinical development and commercialization of novel gene therapies. The agreement is designed to accelerate gene therapy drug development across the field in order to address diseases in need of treatments and thereby ultimately reach more patients. As part of the agreement, an innovative platform development effort will be initiated with a focus on discovering additional next generation Anc-AAVs. By applying its AAV manufacturing technology innovation, Lonza agrees to work towards the establishment of modern best-in-class large-scale manufacturing platforms for Anc80 and any future vectors generated out of Dr. Vandenberghe’s lab. The agreement comes only months after Lonza broke ground in April 2016 to construct a state-of-the-art viral gene and cell therapy manufacturing facility in Pearland, TX (USA). The new facility, expected to come online at the end of 2017, is anticipated to be one of the largest facilities in the world for the supply of clinical and commercial grade viral-based gene therapies. Under the agreement Lonza will fund research at the Grousbeck Gene Therapy Center at Massachusetts Eye and Ear® to discover, characterize and develop next-generation gene transfer reagents in order to improve upon important limitations of current AAVs, including pre-existing immunity, manufacturing yields, immunogenicity, tissue tropism, and specificity. As part of the agreement, Massachusetts Eye and Ear® grants Lonza the exclusive position to commercially license Anc-AAV while it retains certain commercial and academic rights, including the ability to commercialize self-directed gene therapy programs and all rights in the challenging space of ultra-rare diseases.
Financial terms:
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