Date: 2013-12-19
Type of information: Licensing agreement
Compound: alpha-2c adrenoceptor antagonists including a clinical phase compound ORM-12741
Company: Orion Corporation (Finland) Janssen Pharmaceuticals (J&J - USA)
Therapeutic area: Neurodegenerative diseases
Type agreement: licensing
Action mechanism: ORM-12741 is a selective alpha-2C adrenoceptor (AR) antagonist. It is the first drug developed to target this specific subtype of adrenergic receptors in the brain. Orion research team believes that in conditions like Alzheimer\'s disease, psychotic disorders and depression the impaired cognitive functioning of the patients is further worsened with varying degrees of stress and that alpha-2C adrenoceptor antagonist blockade can provide beneficial stabilization of neurotransmission and improve both cognitive performance and behavioral symptoms. In line with this ORM-12741 has demonstrated efficacy in rodent models suggesting beneficial effects on these symptoms.
Disease: Alzheimer\'s disease
Details:
Financial terms: According to the agreement, Orion will receive an upfront payment of $31 million and is eligible to receive milestone payments from Janssen upon successful completion of certain development and commercialization events, as well as royalties on future sales. Orion will use the majority of the up-front payment over the next few years against the costs of the additional Phase IIa study sponsored by Orion.
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