Date: 2012-06-13
Type of information: Licensing agreement
Compound: POTELLIGENT® CHOK1SV Cell Line
Company: Lonza (Switzerland) Biowa (Japan) FivePrime Therapeutics (USA)
Therapeutic area: Cancer - Oncology
Type agreement: licensing
commercialisation
Action mechanism: POTELLIGENT® CHOK1SV is a host cell line for manufacturing recombinant antibodies that combines the power of BioWa’s engineered glycosylation POTELLIGENT® Technology with the advantages of Lonza’s proprietary GS Gene Expression System™, which includes the industry-leading CHOK1SV cell line.
Disease:
Details: Five Prime Therapeutics has entered into research and commercial agreements with BioWa, Inc. and Lonza to use their POTELLIGENT® CHOK1SV Cell Line for the research, development and production of multiple proprietary antibodies in FivePrime’s oncology pipeline. The POTELLIGENT® CHOK1SV Cell Line retains the desirable features of a high-producing cell line (robust, high-yielding, scalable), with the advantage of a proven bioprocess platform for the CHOK1SV cell line. Antibodies produced by this cell line exhibit enhanced antibody dependent cellular cytotoxicity (ADCC) and can exert potent cytotoxic effects even when their target antigen is low. In addition, they work in whole blood and retain all other desirable features of common antibodies.
The POTELLIGENT® CHOK1SV cell line is available under a license to Lonza customers as an option in cell line construction service offering.
Financial terms:
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