Date | Compound | Laboratory | Indication | Type of Information |
---|---|---|---|---|
2014-12-23 | conjugate of pteroi acid and S0456 near infrared dye | On Target Laboratories (USA - IN) | diagnostic for the management of ovarian cancer |
Granting of the orphan status in the US |
2014-05-27 | p38 mitogen-activated kinase inhibitor | Array BioPharma (USA - CO) | dilated cardiomyopathy, including dilated cardiomyopathy secondary to lamin A/C gene mutations |
Granting of the orphan status in the EU |
2015-12-14 | live attenuated Listeria monocytogenes delta actA/delta inlB strain expressing human mesothelin | Aduro Biotech (USA - CA)/Medpace (Germany) | mesothelioma |
Granting of the orphan status in the EU |
2016-09-29 | masitinib mesilate in combination with riluzole | AB Science (France) | amyotrophic lateral sclerosis |
Submission of a Market Application in the EU |
2015-04-02 | altiratinib | Deciphera Pharmaceuticals (USA - KS) | glioblastoma multiforme |
Granting of the orphan status in the US |
2014-05-14 | [a-N-(2\'succinyl-paclitaxel)Thr]-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-[epsilon-N-(2\'succinyl-paclitaxel)Lys]-Arg-Asn-Asn-Phe-[epsilon-N-(2\'succinyl-paclitaxel)Lys]-Thr-Glu-Glu-Tyr | Angiochem (Canada) | glioblastoma multiforme |
Granting of the orphan status in the US |
2015-04-02 | acetylcysteine effervescent tablets for oral solution | Arbor Pharmaceuticals (USA - GA) | prevention of hepatic injury from acetaminophin overdose |
Granting of the orphan status in the US |
2015-06-19 | adeno associated virus with modified transthyretin and sequence encoding factor IX variant gene | Baxter now Baxalta (USA - IL) | hemophilia B |
Granting of the orphan status in the EU |
2014-09-24 | aldoxorubicin | CytRx Corporation (USA - CA) | ovarian cancer |
Granting of the orphan status in the US |
2014-09-24 | aldoxorubicin | CytRx Corporation (USA - CA) | glioblastoma multiforme |
Granting of the orphan status in the US |
2014-09-24 | aldoxorubicin | CytRx Corporation (USA - CA) | small cell lung cancer |
Granting of the orphan status in the US |
2014-12-23 | antagonist of the endosomal Toll-like receptors (TLRs) 7, 8, and 9 | Idera Pharmaceuticals (USA - CA) | Waldenstrom\'s macroglobulinemia |
Granting of the orphan status in the US |
2014-10-22 | autologous adipose derived mesenchymal stromal cells | Mayo Clinic (USA - MN) | amyotrophic lateral sclerosis |
Granting of the orphan status in the US |
2014-10-21 | autologous bone marrow CD34+ cells transduced ex vivo with a self activating HIV-1 -based lentiviral vector, EFS-ADA | Donald B. Kohn, MD - Professor, UC-UCLA Microbiology (USA - CA) | adenosine deaminase deficient severe combined immunodeficiency (ADA-SCID) |
Granting of the orphan status in the US |
2014-06-10 | autologous genetically modified human dermal fibroblasts | Fibrocell Technologies (USA - PA) | dystrophic epidermolysis bullosa |
Granting of the orphan status in the US |
2015-12-08 | bendamustine for 50ml admixture | Eagle Pharmaceuticals (USA - NJ) Teva Pharmaceutical Industries (Israel) | indolent B-cell Non-Hodgkin\'s lymphoma |
Granting of a Market Authorisation in the US |
2015-12-08 | bendamustine for 50ml admixture | Eagle Pharmaceuticals (USA - NJ) Teva Pharmaceutical Industries (Israel) | chronic lymphocytic leukemia |
Granting of a Market Authorisation in the US |
2014-10-22 | bi-shRNA furin and GMCSF autologous tumor cell vaccine | Gradalis (USA - TX) | Ewing\'s sarcoma |
Granting of the orphan status in the US |
2014-07-31 | binimetinib | Array BioPharma (USA - CO) | ovarian cancer |
Granting of the orphan status in the US |
2014-02-14 | bisantrene HCl | Update Pharma (USA - CA) | acute myeloid leukemia |
Granting of the orphan status in the US |
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