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New approach to single-cell RNA structure sequencing unveils biomarkers for human development and disease

New approach to single-cell RNA structure sequencing unveils biomarkers for human development and disease Different cells have different RNA structures and studying those structures offers insights into cell functions. © A*STAR’s GIS Researchers from A*STAR’s Genome Institute of Singapore (GIS) have found an innovative approach to sequencing single-cell RNA to…..

NIH study shows how genes in retina get regulated during development

NIH study shows how genes in retina get regulated during development Genome topology map of human retina development lays foundation for understanding diverse clinical phenotypes in simple and complex eye diseases [caption id="" align="aligncenter" width="555"] This image metaphorically captures the cell differentiation process during retinal organoid development. Loose yarn representing…..

Fragile X syndrome begins developing even before birth

Fragile X syndrome begins developing even before birth Fragile X syndrome (FXS), the most common form of inherited intellectual disability, may be unfolding in brain cells even before birth, despite typically going undiagnosed until age 3 or later. These results could fundamentally change how scientists understand the developmental origins of…..

Drug discovery on an unprecedented scale

Drug discovery on an unprecedented scale [caption id="" align="aligncenter" width="700"] Artistic impression of artificial intelligence in drug design - ©Ina Pöhner[/caption] Boosting virtual screening with machine learning allowed for a 10-fold time reduction in the processing of 1.56 billion drug-like molecules. Researchers from the University of Eastern Finland teamed up with industry…..

Good news for quality control of mRNA medications

Good news for quality control of mRNA medications A mRNA molecule (p-RNA) is mixed with a standard (s-RNA) labelled with stable isotopes (SI) before being digested then characterized using a combination of liquid chromatography and mass spectrometry (LC-MS). The output is analyzed using Ariadne software to yield information on the…..