NIH study shows how genes in retina get regulated during development Genome topology map of human retina development lays foundation for understanding diverse clinical phenotypes in simple and complex eye diseases [caption id="" align="aligncenter" width="555"] This image metaphorically captures the cell differentiation process during retinal organoid development. Loose yarn representing…..
Application of base editors in organoids opens new doors for cancer research The development of new cancer treatments depends on suitable tumor models in the laboratory. Researchers from the Organoid group (Hubrecht Institute) and the Princess Máxima Center have used base editors to simultaneously introduce multiple cancer-related mutations into healthy…..
First human model for Leigh syndrome [caption id="attachment_9893" align="alignright" width="300"] Human brain organoids with mature neurons in green. ©Dr. Agnieszka Rybak-Wolf[/caption] Leigh syndrome is the most severe mitochondrial disease in children. This orphan disease causes severe muscle weakness, movement defects, and intellectual disabilities. It usually leads to death within the…..