Type of information: Clinical trial authorisation
Announcement: clinical trial authorization
Action mechanism: small molecule ATR-258 is based on ground-breaking research into adrenergic signaling by Professor Tore Bengtsson at Stockholm University leading to the discovery of how to selectively stimulate b2-adrenergic receptors to translocate glucose transporter 4 (GLUT4) to the cell membrane. This promotes glucose uptake in skeletal muscle resulting in a reduction of blood glucose levels achieved without insulin. Atrogi believes ATR-258 has the potential to produce a frontline treatment for type 2 diabetes that produces minimal side effects.
Disease: type 2 diabetes
Therapeutic area: Metabolic diseases
Trial details: The Phase I protocol covers three parts, Part A: Single Ascending Dose of the drug candidate given to healthy volunteers, Part B: Multiple Ascending Dose administered to healthy volunteers and Part C: continuous administration of xxxx at a fixed dose during 28 days in patients with type 2 diabetes. Eligible Diabetes patients should have a HbA1c level of 7-9% after a Metformin wash-out period over 4 weeks.