Date: 2016-04-21
Type of
information: Presentation of results at a congress
phase: preclinical
Announcement: presentation of results at the American Association for Cancer Research (AACR) Annual Meeting
Company: Basilea Pharmaceutica (Switzerland)
Product: BAL3833 (CCT3833)
Action
mechanism:
- kinase inhibitor. BAL3833 is an orally available small-molecule panRAF/SRC kinase inhibitor targeting cell proliferation signaling pathways that are associated with tumor growth and resistance development to current therapies. It is the lead compound of a series of kinase inhibitors in-licensed by Basilea in April 2015 under an agreement with The Institute of Cancer Research, London, Cancer Research Technology, the Wellcome Trust, and The University of Manchester. BRAF is mutated in a range of cancers including melanomas, colorectal and serous ovarian cancer. Data from preclinical studies suggest that this class of compounds, targeting the BRAF, CRAF and SRC family kinases, are active in diverse patient-derived models resistant to standard BRAF as well as MEK inhibitor therapies.7 BAL3833 has progressed into a phase 1 study in adult patients with advanced solid tumors including BRAF-mutant and BRAF inhibitor-resistant melanomas. The compound originates from research at The Institute of Cancer Research and the Cancer Research UK Manchester Institute, by scientists funded by Cancer Research UK and the Wellcome Trust.
Disease:
Therapeutic
area: Cancer - Oncology
Country:
Trial
details:
Latest
news:
- • On April 21, 2016, Basilea Pharmaceutica announced that preclinical data on BAL3833 were presented at the American Association for Cancer Research (AACR) annual meeting. BAL3833 is currently in Phase 1. In a late-breaking research session, the groups of Prof. Caroline Springer (The Institute of Cancer Research, London) and Prof. Richard Marais (Cancer Research UK Manchester Institute, University of Manchester) reported that the novel panRAF/SRC kinase inhibitor BAL3833, also known as CCT3833, has anti-cancer activity in KRAS-driven in vitro and in vivo tumor models via inhibition of the RAF and SRC family kinases. KRAS is an important driver of tumor cell growth, with high rates of KRAS mutation found in several major cancer types, including pancreatic, colorectal and non-small-cell lung cancer. BAL3833 inhibits mutant BRAF as well as the CRAF and SRC protein kinases and was initially developed to address the increasing medical need of melanoma patients who progress on current mutant BRAF pathway inhibitors. The data presented show that BAL3833 may also be effective in non-melanoma KRAS-mutant cancers, potentially providing a new therapeutic option for these patients. Orally administered BAL3833 is currently being explored in a phase 1 clinical study in patients with solid tumors, including BRAF-mutant and BRAF inhibitor-resistant melanomas.
Is
general: Yes
