Date: 2011-03-21
Type of information:
phase: 2b
Announcement: interim results
Company: Quark Pharmaceuticals (USA) Silence Therapeutics (UK)
Product: PF-04523655 (RTP801I-14)
Action mechanism: PF-04523655 incorporates Silence’s AtuRNAi technology and was sub-licensed to Pfizer Inc. by Quark Pharmaceuticals.
Disease: diabetic macular edema
Therapeutic area: Ophtalmological diseases
Country:
Trial
details: The DEGAS study is a Phase 2b prospective, randomized, multi-center, dose-ranging, comparator study that evaluates the efficacy and safety of PF-04523655 (RTP801I-14) versus Lucentis® in patients with diabetic macular edema. This study evaluated the safety and efficacy of PF-04523655 (RTP801I- 14) in patients with diabetic macular edema (DME). 184 patients were randomly assigned to four treatment groups; three dose levels of PF-04523655 (RTP801I-14) (0.4mg, 1mg, and 3mg) or laser. The study was designed with a primary endpoint of mean visual acuity improvements over baseline at 24 months.
Latest
news: Silence Therapeutics has announced that its partner, Quark Pharmaceuticals, has received results from a prospective randomized Phase 2 trial, the DEGAS study. The study evaluated the safety and efficacy of PF-04523655 (RTP801I- 14) in patients with diabetic macular edema (DME).
Interim results at 12 months showed there were no drug related Serious Adverse Events Best results achieved at 3mg dose level, mean improvement from baseline on a visual acuity test was 5.8 letters for all patients enrolled in the 3mg dose group versus 2.4 letters on average in patients treated with laser photocoagulation control (the current standard of care)
Separate secondary analysis of the 111 patients who completed the 12 month follow up visit showed mean improvement from baseline on a visual acuity test in the 3mg group of 9.1 letters versus 3.2 letters on average (p<0.01) in patients treated with laser photocoagulation control
The study was terminated at 12 months based upon this interim analysis suggesting that higher doses would be necessary to produce a therapeutic effect sufficiently superior to the current standard of care to benefit patients over the long term given emerging new therapeutic modalities. Based upon these results, and in view of a dose related effect on vision, Quark and Pfizer have mutually agreed that a Phase 2b study will be conducted by Quark at its own expense under a protocol mutually agreed upon by Quark and Pfizer.
Quark will test higher doses of PF-04523655 (RTP801I-14) and determine the optimal dose for pivotal Phase 3 studies. It is designed as a randomized, dose ranging comparator study that will evaluate the safety and efficacy of PF-04523655 (RTP801I-14) versus Lucentis®.
Quark and Pfizer also agreed to amend their existing agreement in order to enable Quark to conduct the Phase 2b study. Under the amended agreement, Pfizer has materially increased the development and product approval milestone payments associated with the first ophthalmic use of PF-04523655 (RTP801I-14), as well as the royalty rates for the product. Under the amended license agreement, if Pfizer chooses to continue development of PF-04523655 (RTP801I-14) following review of the Phase 2b data, Quark may receive total developmental and sales milestones payments for all indications, including those related to successful completion of the Phase 2b study, of up to approximately $700 million.
