Date: 2016-06-06
Type of information: Presentation of results at a congress
phase: preclinical
Announcement: presentation of results at the Gordon Research Conference for Fragile X and Autism-Related Disorders
Company: Anavex Life Sciences (USA - NY)
Product: ANAVEX2-73 (tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride)
Action
mechanism: Anavex2-73 is an agonist of the intracellular sigma-1 chaperone protein. The compound is a mixed muscarinic receptor/sigma 1 ligand. It has been reported to have memory-preserving and neuroprotective effects in mice treated with the muscarinic receptor antagonist scopolamine, with synthetic ABêta oligomer injection, or with the NMDA receptor agonist dizocilpine. A recent study suggested that Anavex 2-73 may block tau hyperphosphorylation.
Disease: fragile X syndrome
Therapeutic area: Rare diseases - Genetic diseases
Country:
Trial details:
Latest
news: * On June 6, 2016, Anavex Life Sciences announced positive data of ANAVEX 2-73 in an exploratory study in a Fragile X syndrome model presented at the Gordon Research Conference for Fragile X and Autism-Related Disorders, being held June 5-10, 2016 in Mount Snow, VT. Dosing of ANAVEX 2-73 for 14 days in a Fragile X syndrome mouse model was followed by a battery of behavioral tests that are linked to pathophysiological signs of Autism-related disorders and Fragile X syndrome: hyper-locomotion, associative learning, and marble burying. Treatment with ANAVEX 2-73 significantly improved all behaviors tested. ANAVEX 2-73 significantly reversed the hyperactivity and impairment in learning and memory (p?0.0001), to the same levels observed in vehicle-treated wild-type mice. ANAVEX 2-73 also yielded a partial effect in the marble burying experiment (p?0.05). The study was sponsored by FRAXA, via the FRAXA Drug Validation Initiative, and performed by Fraunhofer Chile Research, Santiago, Chile. The poster is titled “Sigma-1 Receptor Agonists as Potential Treatment Options for Autism Spectrum Disorders: Pre-clinical Studies with ANAVEX 2-73 in a Fragile X Model”.
