Date: 2016-02-22
Type of information: Results
phase: preclinical
Announcement: results
Company: OncoQR ML (Austria) TYG Oncology (UK)
Product: TYG100
Action
mechanism: therapeutic vaccine/immunotherapy product. TYG100 (OQR100 - out licensed to TYG-Oncology) is a adjustable cancer immunotherapy (ACI), for treatment of gastroenterological cancers such as pancreatic, stomach and colon cancer. TYG100 contains G17 (little gastrin) as tumour associated autoantigen.
Disease: pancreatic cancer
Therapeutic area: Cancer - Oncology
Country:
Trial details:
Latest
news: * On February 22, 2016, OncoQR ML, a company developing Next Generation Checkpoint Control Cancer Immunotherapies, announced that in a preclinical trial in a highly relevant non-human primate (NHP) model its pancreatic cancer vaccine TYG100 was able to induce a strong and clinically relevant immune response. This immune response occurred in all treated individuals within just 2 weeks after a single vaccination. No side-effects were observed. The trial also showed that concomitant standard chemotherapy (gemcitabine) does not impair the immune response in a relevant way. This finding shows that treatment with TYG100 can be initiated in parallel to chemotherapy. Since pancreatic cancer is an extremely aggressive disease where the average time from diagnosis to death is measured in months, not years, an immunotherapy that can be initiated together with, not after, chemotherapy, and that elicits the desired immune response very fast, would fundamentally improve the treatment of pancreatic cancer patients. In this trial, again a clear correlation between dose and immune response was observed. The trial thereby extends what has already been established in other trials that OncoQR ML conducted in different indications with vaccines based on the same S-TIR™ technology platform technology as TYG100: the completely controllable modification of the patient's immune system by suspension of the relevant checkpoint control. TYG100 is designed to elicit an immune response against gastrin (G17). This target was selected because it was well established in clinical phase III trials with an inferior predecessor vaccine G17DT, that an appropriate immune response against G17 significantly prolongs survival by several months. While this survival benefit compares very favorably against current standard chemotherapy (Gemcitabine), in said clinical trials the required immune response was only achieved after several vaccinations and only in a statistically too small subset of patients. The correlation between immune response against G17 and survival benefit was appreciated by drug authorities, but the overall immunogenicity was deemed not sufficient for market approval. By contrast, TYG100 could consistently elicit a clinically relevant immune response which is several orders of magnitude stronger than even in the most favorable cases in the clinical trials in pancreatic cancer mentioned. In contrast to G17DT, TYG100 was confirmed to be immunogenic in all individuals tested just 2 weeks after a single vaccination and did not show any side effects. The data from the study of TYG100 thus showed that OncoQR ML's experimental immunotherapy does elicit a strong and completely controllable immune response against pancreatic cancer in all individuals vaccinated, very fast, and even under concomitant chemotherapy.
