Date: 2015-04-26
Type of information: Initiation of development program
phase: preclinical
Announcement: initiation of a development program
Company: Can-Fite BioPharma (Israel)
Product: CF602
Action
mechanism: CF602 is a novel A3 adenosine receptor allosteric modulator, enhancing the affinity of the natural ligand adenosine to its A3 adenosine receptor. Since adenosine accumulates in the microenvironment of the pathological cells, CF602 effect is a differential one and is believed not to affect normal body cells and tissues. The mechanism of action related to the improvement of sexual dysfunction stems out of the fact that adenosine, like nitric oxide, is a potent and short-lived vasorelaxant that functions via cAMP signaling to promote smooth muscle relaxation and penile erection.
Disease: sexual dysfunction
Therapeutic area:
Country:
Trial details:
Latest
news: * On December 9, 2014, Can-Fite BioPharma, a biotechnology company with a pipeline of proprietary small molecule drugs that address inflammatory and cancer diseases, reported that it will initiate a pre-clinical development program of its next generation drug CF602 for the indication of sexual dysfunction. Upon successful completion, the company intends to file an IND with the FDA to allow human Phase I studies. Can-Fite reports has received positive pre-clinical data conducted in experimental animal models demonstrating that CF602 has improved sexual dysfunction in a dose dependent manner. Can-Fite has a strong intellectual property position which includes an issued \"composition of matter\" patent and other pending patent applications protecting the use for sexual dysfunction. GlobalData estimates the value of the erectile dysfunction therapeutic market to be approximately $2.7 billion with few drugs in the market which include Viagra, Cialis and Levitra.
