Date: 2016-06-17
Type of information: Development agreement
Compound: cellular immunotherapy products
Company: Cell Medica (UK) Baylor College of Medicine (USA - TX)
Therapeutic area: Cancer - Oncology
Type agreement: development licensing
Action mechanism: cell therapy/immunotherapy product/CAR-T cell therapy
Disease:
Details: * On June 17, 2016, Cell Medica and Baylor College of Medicine have signed an exclusive licensing agreement and a co-development partnership to create next generation cellular immunotherapy products for the treatment of cancer. This new collaboration is expected to generate a significant number of new products for Cell Medica’s cellular immunotherapy pipeline. It provides the Company with an exclusive license over several Baylor cell and gene technologies and an option to license new products introduced into the co-development partnership by Baylor’s leading research teams in the field of genetically engineered immune cells. The collaboration will build upon the recent clinical success of advanced chimeric antigen receptors (CARs) to enable human immune cells to recognise and kill cancer cells expressing tumour associated antigens. Five product programs have been defined for the initial development plan focused on the application of CAR technology to natural killer T (NKT) cells as a novel immune cell type with biological properties that may be particularly effective for targeting solid tumours. NKT cells are known to infiltrate tissues where solid tumours arise and kill both malignant cells and cancer-enabling cells such as the tumour associated macrophages. The development plan also includes a genetically engineered T cell receptor (TCR) for use in NKT cells and T cells. Cell Medica is a cellular immunotherapy company, focused on the development, manufacture and marketing of cell-based therapeutics for the treatment of cancers and infectious disease. As at 31 January 2016, the Group had a 27.0% interest in the issued share capital of the Company with such interest having a net fair value of £21.0 million. Baylor’s Centre for Cell and Gene Therapy (CAGT) has more than 20 years of experience working with genetically modified immune cells for the treatment of cancer. It has conducted more than 40 clinical studies investigating cellular immunotherapies for the treatment of cancer.
Financial terms: Cell Medica has paid an up-front fee for the exclusive licensing arrangements and will make additional payments to exercise its exclusive option to licence future products. Baylor is eligible to receive further payments related to late stage clinical, regulatory approval and sales milestones, as well as single digit royalties for the successful development of specific products. The financial terms have not been disclosed.
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