Date: 2016-01-07
Type of information: Nomination
Compound:
Company: Adaptimmune (UK)
Therapeutic area: Autoimmune diseases
Type agreement: nomination
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Details: * On January 7, 2016, Adaptimmun announced that it is expanding its T-cell therapy development activities to target certain autoimmune diseases. Professor P. Julian Dyson, Ph.D. has joined the company as the head of the Autoimmune Group with responsibility for leading the autoimmune expansion, including the identification and validation of targets, and preclinical assessment of enhanced affinity TCRs directed against autoimmune targets. Professor Julian Dyson joins Adaptimmune as Head of the new Autoimmune Group at the company’s research laboratories in Oxfordshire, U.K., with responsibility for leading the development of T-cell immunotherapy for autoimmune indications/conditions. Prof. Dyson brings 28 years of research experience in immunology working at the Medical Research Council and, since 2007, as Professor of Immunology at Imperial College London. The major focus of Prof. Dyson’s research has been on the regulation of immune responses. He has published over 100 papers including articles in Cell, Nature and PNAS. Among his professional activities, he has been a frequent invited lecturer at the Universities of Cambridge, Oxford, Cardiff, Southampton, London, Edinburgh, Milan, and Kyoto. Prof. Dyson received a BSc degree in Biochemistry from the University of Sussex and a Doctorate from the University of London. Adaptimmune’s goal is to restore the function of the immune system and inhibit the autoimmune response by delivering affinity enhanced Regulatory T-cells, called Tregs, to the site of the disease. Tregs are a subpopulation of immune cells that are involved in maintenance of self-tolerance in healthy individuals and are thought to suppress the action of potential autoreactive lymphocytes that would otherwise recognize and destroy normal tissue, causing autoimmune diseases. Adaptimmune believes that by delivering affinity enhanced antigen-specific Tregs to the site of an autoimmune disease, it can inhibit the autoimmune response and restore self-tolerance within the immune system, thus reducing the impact of the disease. The company believes that this approach may provide a better tolerated approach with fewer side effects than currently approved therapeutic options. Adaptimmune is currently validating a number of initial targets that are expressed in high amounts only on tissues involved in certain autoimmune diseases; these can then be used to develop specific affinity enhanced T-cell therapies.
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