Date: 2015-07-15
Type of information: Nomination
Compound:
Company: CytoDyn (Canada)
Therapeutic area: Infectious diseases
Type agreement: nomination
Action mechanism:
Disease:
Details: * On July 15, 2015, CytoDyn, a biotechnology company focused on the development of new therapies for combating human immunodeficiency virus (HIV) infection, announced Paul J. Maddon, M.D., Ph.D., a biotechnology entrepreneur and an inventor of PRO 140, has been named Senior Science Advisor to CytoDyn. In this capacity, Dr. Maddon will advise CytoDyn on the development program for PRO 140. Dr. Maddon is the founder and Vice Chairman of Progenics Pharmaceuticals, Inc. and also serves as a director and consultant to several biotechnology and specialty pharmaceutical companies. He previously served as Chairman, Chief Executive Officer, and Chief Science Officer of Progenics. Dr. Maddon is a molecular virologist and immunologist who has made major contributions to our understanding of HIV entry and infection. As a graduate student at Columbia University, he isolated the gene encoding CD4 and demonstrated that CD4 serves as the primary receptor for entry of HIV into immune system cells. While at Progenics, Dr. Maddon and his collaborators discovered that a second receptor, CCR5, is also required for HIV entry. He led the discovery and development of PRO 140, a humanized monoclonal antibody to CCR5 designed to treat HIV infection. Dr. Maddon has served on the editorial board of Journal of Virology and chaired and served on numerous scientific advisory committees of the National Institutes of Health and Department of Defense. He has also received several honors and has been awarded many federal research grants and contracts. At Columbia University, he received a B.A. from the College, an M.D. from the College of Physicians and Surgeons, and a Ph.D. in biochemistry and molecular biophysics from the Graduate School of Arts and Sciences.
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