Date: 2014-10-08
Type of information: Production agreement
Compound: tafoxiparin
Company: Dilafor (Sweden) Opocrin (Italy)
Therapeutic area: Women health
Type agreement: manufacturing production
Action mechanism: Tafoxiparin is a heparansulphate mimetic, a propriety polysaccharide based drug developed by Dilafor. Women that experience protracted and complicated labor have deficiency in heparansulphate which is a naturally occurring polysaccharide and plays an important role in labor. Preclinical and clinical data show that tafoxiparin fulfills the role of heparansulphate and works in conjunction with naturally occurring molecules important in child birth. Labor dystocia/protracted labor has an incidence of 45% of all pregnant women. It is associated with a number of both long and short term maternal and fetal complications such as emergency caesarean sections, postpartum hemorrhages, vaginal tears, anal ruptures, meconium-stained amniotic fluid and asphyxia.
Disease: obstetrical indications
Details: * On October 8, 2014. Dilafor and Opocrin announced that they have entered into a commercial supply and partnership agreement. In the agreement, Opocrin will concurrently make an investment in Dilafor and be appointed as the main commercial manufacturing partner for Dilafor’s candidate drug tafoxiparin for the European, US, CIS and Japanese markets. Furthermore, Opocrin will supply manufacturing services during clinical development of tafoxiparin and the companies will jointly develop the commercial manufacturing of tafoxiparin. The partnership will initially focus on the clinical supply of tafoxiparin in support of the Phase II and Phase III clinical trial program in obstetrical indications. Opocrin will support the company with services and manufacturing needed to take tafoxiparin through those clinical studies and by preparing for the commercial supply of tafoxiparin for major markets such as US, EU, Japan and CIS. Further details on the investment and the terms of the agreement are not being disclosed.
Financial terms:
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