Date: 2013-11-04
Type of information: Development agreement
Compound: POL7080
Company: Roche (Switzerland) Polyphor (Switzerland)
Therapeutic area: Infectious diseases
Type agreement: development
licensing
commercialisation
Action mechanism:
Disease: infections caused by Pseudomonas aeruginosa
Details: * On November 4, 2013, Roche and Polyphor have entered into an exclusive worldwide license agreement to develop and commercialise Polyphor’s investigational macrocycle antibiotic, POL7080, for patients suffering from bacterial infections caused by Pseudomonas aeruginosa. POL7080 belongs to a new class of antibiotics that kills Pseudomonas aeruginosa by a novel mode of action. It has demonstrated clinical safety and tolerability in a Phase I clinical trial and holds promise for the treatment of serious and often life-threatening bacterial infections caused by multi-drug-resistant (MDR) Pseudomonas species.
Financial terms: Under the terms of the agreement, Roche will make an upfront payment of CHF 35 million to Polyphor as well as payments upon reaching certain development, regulatory and commercial milestones, potentially up to CHF 465 million. In addition, Polyphor is entitled to receive tiered double-digit royalties on product sales. Polyphor will retain the option to co-promote an inhaled formulation of POL7080 in Europe. The transaction is subject to customary regulatory clearances including termination of the applicable Hart-Scott-Rodino waiting period.
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