Agreements

* On October 24, 2013,  Atheris Laboratories, a company specialized in venom-based drug discovery and lead optimization, and Debiopharm Group have announced the signature of a collaboration agreement regarding the Atheris “Reverse-Discovery”™ lead optimization platform. Collaboration with Atheris is expected to accelerate Debiopharm’s ongoing lead optimization program in project Debio 0826, whose aim is to develop a peptide drug against an innovative oncology target through a “Venomics” approach using Debiopharm’s expertise in the discovery, development and formulation of peptides.

This collaboration aims to improve drugability features (increasing efficacy, potency, selectivity and stability, while reducing possibly unwanted side-effects such as toxicity) of one promising lead candidate peptide identified in animal venom by Atheris, Debiopharm and the Ecole polytechnique fédérale de Lausanne (EPFL). Lead optimization will be carried out using Atheris’ proprietary “Reverse-Discovery” probabilistic algorithms. Candidates will be identified and produced using a multiplex synthetic venom platform developed by Atheris in partnership with the teams of Prof. Oliver Hartley at the University of Geneva and Dr Frédérique Lisacek from the Swiss Institute of Bioinformatics with financial support from the Swiss Commission for Technology and Innovation (CTI).