Date: 2016-05-31
Type of information: Presentation of results at a congress
phase: 2
Announcement: presentation of results at the 84th European Atherosclerosis Society (EAS) Congress in Innsbruck, Austria.
Company: Regeneron Pharmaceuticals (USA - NY)
Product: evinacumab (REGN1500)
Action
mechanism: monoclonal antibody. Evinacumab is an investigational monoclonal antibody to angiopoietin-like protein 3 (ANGPTL3). ANGPTL3 acts as an inhibitor of lipoprotein lipase and endothelial lipase, and appears to play a central role in lipoprotein metabolism.
Disease: homozygous familial hypercholesterolemia
Therapeutic area: Rare diseases - Genetic diseases - Metabolic diseases
Country:
Trial details:
Latest
news: * On May 31, 2016, Regeneron Pharmaceuticals announced that positive preliminary results from an ongoing proof-of-concept study of evinacumab (REGN1500) in patients with homozygous familial hypercholestrolemia (HoFH) were presented at the 84th European Atherosclerosis Society (EAS) Congress in Innsbruck, Austria. The interim data from the first 4 patients treated in this study showed that evinacumab added to current lipid-lowering therapy reduced low-density lipoprotein cholesterol (LDL-C) levels by an additional 55 percent (mean reduction; range 25 to 90 percent) at week 4 compared to baseline. HoFH is the most severe form of hypercholesterolemia. While rare, occurring in approximately 1 to 2 people per million, untreated patients can have "bad cholesterol" or LDL-C levels ranging from 500 to 1000 mg/dL, compared to normal LDL-C levels of less than 130 mg/dL. Due to these high levels of LDL-C, patients with HoFH are at an extreme risk of premature cardiovascular disease. Without treatment, patients typically present with signs and symptoms of atherosclerotic cardiovascular disease before the age of 20. The ongoing single-arm, open label, proof-of-concept study is targeting to enroll up to 8 patients with HoFH. Study patients' diagnosis is confirmed both genetically and phenotypically. Current lipid-lowering therapy was maintained from 4 weeks before baseline through the 26-week treatment and observation period. Patients on LDL apheresis within 4 weeks prior to screening were excluded. For the 4 patients reported here, all were receiving maximum doses of statin plus ezetimibe with one patient additionally receiving lomitapide 20 mg. Evinacumab was dosed as a single 250 mg subcutaneous injection at baseline and subsequently, at week 2, as a 15 mg/kg intravenous (IV) infusion. The primary endpoint of the study was the mean percent change in LDL-C levels from baseline to week 4. After 4 weeks of treatment and 2 weeks after administration of the 15 mg/kg IV dose, the mean reduction in LDL-C in the 4 patients was 55 percent (primary endpoint of the study). Among these 4 patients, the percent reductions in LDL-C ranged from 25 to 90 percent. Overall, the patients enrolled in the study saw their mean LDL-C levels fall from 331mg/dL at baseline to 175mg/dL at week 4. Evinacumab was generally well tolerated and there were no adverse events leading to discontinuation. The most common drug-related adverse events were injection-site reactions, which were mild in severity.
