Date: 2015-09-23
Type of information: Results
phase: preclinical
Announcement: results
Company: Addex Therapeutics (Switzerland) Janssen Pharmaceuticals, a J&J company (USA - NJ)
Product: ADX71149
Action
mechanism: mGluR2 negative allosteric modulator. ADX71149 is a novel, first-in-class potent, oral, small molecule positive allosteric modulator (PAM) of metabotropic glutamate receptor 2 (mGluR2), a Family C class of G Protein Coupled Receptor (GPCR). The development of ADX71149 is part of a worldwide research collaboration and license agreement between Addex and Janssen Pharmaceuticals, Inc. to discover, develop and commercialize a novel mGluR2 PAM medication for the treatment of anxiety, schizophrenia and other undisclosed indications. Under the terms of the agreement, Addex is eligible for up to a total of €112 million in milestone payments based on potential development and regulatory achievements. In addition, Addex is eligible for low double-digit royalties on sales of any mGluR2 PAM medication developed under the agreement.
Disease: epilepsy
Therapeutic area: Neurological diseases - CNS diseases
Country:
Trial details:
Latest
news: * On September 23, 2015, Addex Therapeutics announced that ADX71149 demonstrated synergistic efficacy with levetiracetam (a globally commercialized antiepileptic drug) in preclinical models of epilepsy. ADX71149 has been extensively profiled, by Addex Partner, Janssen Pharmaceuticals Inc., in preclinical models of epilepsy showing efficacy both stand alone and in combination with SV2A ligands including levetiracetam. These data are included in patent application number WO2015110435. In the 6 Hz psychomotor seizure test, ADX71149 given subcutaneously showed robust protection with ED50 determined to be 12.2 mg/kg and 21 mg/kg at 32 mA and 44 mA, respectively. In combination studies with varying doses of levetiracetam, a fixed dose of ADX71149 increased the potency of levetiracetam leading to an approximate 35-fold shift in its ED50. Conversely, using a fixed dose of levetiracetam with varying doses of ADX71149, levetiracetam increased the potency of ADX71149, leading to an approximate 14-fold shift in its ED50, suggesting a positive pharmacodynamic relationship or strong synergistic effect for the two molecules when given in combination.
