Date: 2015-04-27
Type of information: Presentation of results at a congress
phase: preclinical
Announcement: presentation of results at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) in Copenhagen, Denmark
Company: Taxis Pharmaceuticals (USA - NJ)
Product: TXA709
Action
mechanism: antibiotic. TXA709 inhibits the bacterial protein FtsZ, which plays an essential role in bacterial cell division. The inhibition of FtsZ is considered a novel mechanism of action.
Disease: multidrug-resistant bacteria infections
Therapeutic area: Infectious diseases
Country:
Trial details:
Latest
news: * On April 27, 2015, Taxis Pharmaceuticals, a drug-discovery company focused on developing a new class of antibiotic agents to treat life-threatening, multidrug-resistant bacterial infections, announced the presentation of data demonstrating the promise of its lead clinical candidate, TXA709, in combating antibiotic resistance. In a poster presentation at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) in Copenhagen, Denmark, researchers presented pre-clinical data highlighting the unique mechanism of action and potent bactericidal activity of TXA709 against Staphylococcus aureus isolates that are resistant to current standard-of-care antibiotics including vancomycin, daptomycin and linezolid. TXA709 inhibits the bacterial protein FtsZ, which plays an essential role in bacterial cell division. The inhibition of FtsZ is considered a novel mechanism of action, making TXA709 an appealing product candidate as researchers work to develop antibacterial agents to address the public health crisis stemming from the growing frequency of antibiotic resistance. \"Methicillin-resistant Staphylococcus aureus, or MRSA, is a major contributor to the global antibiotic resistance problem. Our research shows that TXA709, which the body converts into a benzamide compound called TXA707, offers superior in vivo efficacy against MRSA and other resistant Staphylococcus aureus strains, compared to standard-of-care antibiotic agents,\" explained Edmond J. LaVoie, Ph.D., lead author of the poster, professor and chair, Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, and a co-founder of Taxis Pharmaceuticals. \"Its unique inhibition of the FtsZ protein translates into potent bactericidal activity, enhanced metabolic stability and improved pharmacokinetic properties, making TXA709 a potentially valuable tool in the global struggle against antibiotic resistance.\" Dr. LaVoie and colleagues reported on a series of antibiotic challenge studies in which TXA707, the metabolite of TXA709, maintained potent bactericidal activity against S. aureus isolates with documented resistance or non-sensitivity to methicillin, vancomycin, daptomycin, and linezolid. They also presented an analysis of antistaphylococcal efficacy in a mouse peritonitis model of systemic infection, in which TXA709 was associated with enhanced (two- to four-fold greater) in vivo efficacy against both methicillin-sensitive S. aureus (MSSA) and MRSA strains, compared to another TAXIS compound with a similar mechanism of action. A second-generation FtsZ inhibitor, TXA709 is a prodrug (a biologically inactive compound that can be metabolized in the body to produce a drug) of TXA707, a derivative of benzoic acid that disrupts the form and function of FtsZ. In the presence of TXA707, FtsZ does not function properly, resulting in bacterial cell death that is achieved more rapidly than that observed with standard antibiotics such as vancomycin. Dr. Pilch and colleagues also reported on experiments that validate FtsZ as the bactericidal target of TXA707, which induces the overstimulation of FtsZ polymerization, the process by which FtsZ forms a ring-like structure (called the Z-ring) at the middle of the bacterial cell that serves as a scaffold for the recruitment and organization of other critical components of cellular synthesis, septum formation, and cell division. The extent of this stimulation depends on the TXA707 concentration, he noted. TXA707 disrupts Z-ring formation in bacteria by inducing a filamentous phenotype, as well as mislocalization of FtsZ from the septal Z-ring at midcell to multiple punctate sites (areas marked with points or punctures) throughout the cell. The mislocalization of septal biosynthesis away from midcell results in disrupted cell division and, ultimately, cell death in S. aureus. A pharmacokinetic analysis showed that TXA707 is eliminated approximately six times less rapidly and is associated with superior oral bioavailability relative to PC190723, the metabolite of a first-generation FtsZ inhibitor known as TXY541. Additionally, the volume of distribution of TXA707 was found to be roughly three times greater than that of normal body water in the mouse (0.7 L/kg), indicating that the compound distributes well into the tissue. Taxis Pharmaceuticals is currently scaling up for IND-enabling studies of TXA709.
