Why low DNA methylation at H3K27me3 sites for gene repression In our cells, genes associated with alternative cell fate have to be silenced. DNA methylation and H3K27me3 on the histone are two of the most prevalent chromatin modifications that control the epigenetic gene silencing. These two modifications are mutually exclusive…..
Demonstration of a potent, universal coronavirus monoclonal antibody therapy for all COVID-19 variant Researchers at University of Alabama at Birmingham (UAB), Texas Biomedical Research Institute and Aridis Pharmaceuticals discovered a neutralizing monoclonal antibody that potentially acts as a potent universal coronavirus therapy against SARS-CoV-2 and all its variants of concern,…..
First blood test to diagnose bipolar disorder A team involving researchers from Alcediag, Montpellier University Hospital, Les Toises Psychiatry Centre in Lausanne and Professor David J. Kupfer from the University of Pittsburgh identified and validated a combination of blood biomarkers specific to bipolar disorder. These results, recently published in Nature,…..
New perspective on RNA function: RNA regulates proteins and thereby can control cell growth Scientists are increasingly learning of new reasons to appreciate RNA, and the glycolytic enzyme ENO1 seems to have provided yet another in new research from European Molecular Biology Laboratory (EMBL) this week, as published in Molecular…..
New solution for stem cell manufacturing Researchers have developed a unique 3D printed system for harvesting stem cells from bioreactors, offering the potential for high quality, wide-scale production of stem cells in Australia at a lower cost. [caption id="attachment_10614" align="aligncenter" width="700"] Modular 3D printed microfluidic system©Majid Warkiani et al. Bioresources…..
Coriolis Pharma creates a new campus in Martinsried-Munich Coriolis Pharma, a globally operating contract research and development organization (CRDO) and one of the world leaders in formulation research and development of (bio)pharmaceutical drugs, ATMP´s and vaccines, is expanding its current headquarters to form a new campus as the next step…..
Early signs support revolutionary potential of EU clinical trials regulation The EU Clinical Trials Regulation should help resolve problems caused by its predecessor directive and help meet needs arising from the pandemic. There will be challenges in doing so, but there is already strong evidence of the benefits awaiting. Evidence…..
EUROAPI supports Sanofi’s mRNA vaccine platform with the development of lipid nanoparticles EUROAPI, the European CDMO announced by Sanofi in February 2020, has expanded its collaboration with the French group under the umbrella of their Master Agreement for Development and GMP Manufacturing Services, dated October 1, 2021, to support…..
Arrowhead Pharmaceuticals and Vivo Capital Launch Joint Venture Aimed at Greater China Market Arrowhead Pharmaceuticals, a US company focused on therapies triggering the RNA interference (RNAi), and Vivo Capital, a global healthcare investment firm with offices in Palo Alto, CA, and in China, have formed a new joint venture, Visirna…..
New data-driven approach to help reduce drug costs and treat diseases A new data-driven mechanistic approach that predicts cell types within tissue will help to reduce drug costs and treat diseases that were difficult to develop drugs for, according to a West Virginia University scientist. [caption id="attachment_10508" align="aligncenter" width="700"] WVU…..
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