Date: 2016-05-24
Type of information: Resignation
Compound:
Company: Adaptimmune (UK)
Therapeutic area: Cancer - Oncology
Type agreement: resignation nomination
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Details: * On May 24, 2016, Adaptimmune Therapeutics announced a succession plan for the Chairmanship position that will take effect at the end of 2016. In a planned transition of responsibilities, Chairman, Dr. Jonathan Knowles, will step down from the Board on December 31, 2016. He will be succeeded as Chairman by Mr. David Mott effective from January 1, 2017, and Mr. Mott has been appointed as Vice-Chairman for the duration of the transition period. He has served as a Non-Executive Director of Adaptimmune since September 2014. Dr. Knowles has served as a Non-Executive Director of Adaptimmune since September 2011 and as Chairman since November 2013. Under his chairmanship, the Company has secured its position as a transatlantic leader in immune-oncology during a period that has seen Adaptimmune develop its industry-leading pipeline of SPEAR™ T-cell therapies in solid and hematologic cancers, expand its UK research facilities and establish clinical trials sites across the USA. A new manufacturing plant at its Philadelphia site is slated for launch in 2017 with the potential to enable treatment of up to 1,200 patients per year. Milestone achievements for Adaptimmune during his tenure include: a strategic collaboration agreement with GSK in 2014, expanded in February 2016 to accelerate Adaptimmune’s SPEAR T-cell therapy targeting NY-ESO toward pivotal trials in synovial sarcoma, a solid tumor; initiation of clinical trials of the Company’s unpartnered SPEAR T-cell therapy targeting MAGE-A10 in non-small cell lung cancer and IND acceptance of its unpartnered SPEAR T-cell therapy targeting AFP in liver cancer; a $104 million Series A financing in 2014 followed by an IPO on NASDAQ in 2015 that generated net proceeds of approximately $176 million, and a collaboration with Universal Cell to develop allogeneic T-cell therapies. David Mott has served as a Board member of Adaptimmune since 2014 and has been a General Partner of New Enterprise Associates (NEA), an investment firm focused on venture capital and growth equity investments, since 2008, and leads its healthcare investing practice. NEA is a shareholder of Adaptimmune.
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