Date: 2021-06-15
Type of information: Treatment of the first patient
phase: 2
Announcement: treatment of the first patient
Company: Vectivbio (Switzerland)
Product: apraglutide
Action mechanism: GLP-2 analog. This next-generation GLP-2 analog is being developed for the treatment of short bowel syndrome (SBS). Patients with severe SBS require lifelong intravenous delivery of essential nutrients, referred to as parenteral support, for survival. Apraglutide aims to increase the intestine’s ability to absorb fluids and nutrients, thereby minimizing the burden of parenteral support. With a once-weekly dosing regimen, apraglutide is designed to have best-in-class properties with the goal of improving patients’ quality of life and their ability to thrive. In addition, apraglutide’s development program is designed to generate evidence of meaningful clinical benefit based on patients’ underlying intestinal anatomy in order to enable a patient-tailored treatment approach.
Disease: short bowel syndrome with intestinal failure (SBS-IF)
Therapeutic area: Inflammatory diseases - Gastrointestinal diseases
Country: Belgium
Trial details: STARS Nutrition is a multicenter, open-label Phase 2 Metabolic Balance Study of Apraglutide in Patients with SBS-IF and Colon-in-Continuity trial designed to evaluate the efficacy of once-weekly apraglutide in increasing intestinal energy absorption in SBS-IF CIC patients. The trial is expected to enroll approximately 10 patients and will measure their calorie absorption at weeks 4 and 48. Secondary endpoints will assess changes in PS volume. The initial readout of 4-week absorption data is expected in the first half of 2022. (NCT04964986)
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