Rescue, a new CRISPR platform to expand RNA editing capabilities The new system, dubbed RESCUE, allows RNA edits to be made that were not previously possible. [caption id="attachment_9342" align="aligncenter" width="1024"] The CRISPR family enzyme Cas13 at work. Cas13 (pink), is at the heart of the RESCUE platform, where it uses…..
New prospects for liquid biopsies ? Dr Muneesh Tewari, professor of internal medicine at the U-M Medical School. © Joseph XU. U-M College of Engineering Advancing technology is allowing scientists increasingly to search for tiny signs of cancer and other health issues in samples of patients' blood and urine. These "liquid biopsies"…..
Illustration of lymphocytes attacking cancer cells.©La Jolla Institute How to counteract T cell exhaustion in CAR T cancer therapies? In CAR T cell therapies, a patients' own T cells are removed and genetically engineered to better recognize cancer cells. The cells are then returned to the patient's body, where…..
An inhalable form of mRNA for the treatment of lung diseases About 80 RNA therapeutics are currently in clinical trial. Among these drug candidates, mRNA, which can induce cells to produce therapeutic proteins, holds great promise for treating a variety of diseases. The biggest obstacle to this approach so far…..
Sepsis is an overreaction of the body's immune system to an infection. Cytokines flood the bloodstream in an attempt to fight the infection but also cause blood vessels to become leaky. White blood cells escape from the vessels, causing inflammation and damage to surrounding tissue, ultimately leading to multi-organ failure…..
Cancer develops as a result of the accumulation of mutations in cells. These mutations are not distributed evenly in chromosomes, so some regions hold more than others. A study headed by Institute for Research in Biomedicine (IRB Barcelona) researchers Salvador Aznar Benitah and Fran Supek examined whether the opening of…..
Un entretien avec Régine Rouzier, présidente de la CRO Cap Research Quel élément central conditionne la réussite d’une étude de phase I ? La réussite d’une étude de phase I passe par la rapidité dans l’exécution et par la qualité du travail rendu. Ce sont les deux piliers fondamentaux d’un…..
3D cell and tissue cultures are an emerging field of biomedical research, enabling scientists to study the physiology of human organs and tissues in ways that have not been possible before. However, while these 3D cultures can be generated, technology that accurately assesses their functionality in real time has not…..
The genome editing system CRISPR has become a hugely important tool in medical research. The targeting system can travel to different points on the genome, guided by a short sequence of RNA, where the DNA-cutting enzyme Cas9 then makes the desired edits. However, CRISPR-Cas9 remains limited in the number of…..
Le Guide Marketing Communication Santé 2018 édité par WEYOU GROUP recense les sociétés de conseil, de marketing, de communication et de relations publiques qui oeuvrent dans le champ du médicament et de ses acteurs, les laboratoires pharmaceutiques. Il est un document utile auquel Pharmanalyses et BioPharmanalyses participent conjointement pour établir un…..