Date: 2011-10-24
Type of information: Development agreement
Compound: drug delivery technology (Nano-Capsules) combining nano-particle engineering technology with liquid filled hard capsule technology
Company: Encap Drug Delivery (UK) Lena Nanoceutics (UK)
Therapeutic area:
Type agreement: development
Action mechanism:
Disease:
Details: Encap Drug Delivery and Lena Nanoceutics have announced a collaboration agreement to develop a new drug delivery technology (Nano-Capsules) which combines Lena’s proprietary nano-particle engineering technology with Encap’s liquid filled hard capsule technology. One of the major challenges in oral drug delivery is the development of formulations for improved absorption of poorly soluble and poorly absorbed drugs. There are a number of technologies available to enhance bioavailability, amongst others nano-crystals or nano-particles, and liquid fill formulations. The nano-particle approach results in a decrease in particle size, an increased surface area and therefore a faster dissolution. In some cases, this has been demonstrated to result in increased bioavailability of the active drug. Liquid fill formulations which can be solutions or suspensions of drug in non-aqueous liquids have also proven in many cases to produce significant bioavailability enhancement. [Encap Drug Delivery is global provider of oral drug delivery and pharmaceutical development services (fully integrated analytical and formulation development services, clinical trial manufacturing and high volume commercial manufacturing)]
[Nanoceutics is a technology company which provides enhanced nanoparticle based formulations, addressing issues such as poor bioavailability, for pharmaceutical and healthcare products]
Financial terms: Financial details were not disclosed.
Latest news: Preliminary in-vitro data generated using itraconazole as a model compound has shown improved dissolution rate when both nano-particulate and liquid fill formulations were compared to standard particulate drug formulations. More interestingly, an even greater improvement was found when the nano-particle technology was combined with liquid fill technology.
